Area under the Curve minus baseline
Area under the Curve time infinity
Any of the treatment groups in a randomized trial. Most randomized trials have two “arms”; some have three or more. Open-label studies have one arm.
The cell’s self-destruct mechanism, also known as “programmed cell death.” In this process, the cell dies via “self digestion,” without rupturing and releasing its contents into the surrounding tissue. Without normal cell apoptosis, cells can grow uncontrollably, causing cancer.
Anti-Tumor Necrosis Factor
A component of the body’s immune response. A Y-shaped protein, it is secreted in response to an antigenic stimulus. It neutralizes the antigen it by binding to it.
Molecules that bond to the receptor site of a protein. Unlike agonists, antagonists suppress or inhibit the function of the protein to which they bind.
A negative experience encountered by an individual during the course of a clinical trial, that is associated with the drug. An AE can include previously undetected symptoms, or the exacerbation of a pre-existing condition. When an AE has been determined to be related to the investigational product, it is considered [...]
An unintended reaction to a drug taken at doses normally used in man for prophylaxis, diagnosis, or therapy of disease, or for the modification of physiological function. In clinical trials, an ADR would include any injuries by overdosing, abuse/dependence, and unintended interactions with other medicinal products.